Epidermal growth factors are a family of several proteins naturally present in the body. They are a key component of the cell growth and regeneration process.
On a daily basis, they are responsible for triggering the regeneration of micro-vascular networks and improve wound healing by initiating the synthesis of collagen, elastin and hyaluronic acid.
They were discovered in 1986 by Stanley Cohen and Rita Levi-Montalcini which earned them the Nobel prize in Medicine that year. Only very recently (since less than 10 years), scientists are able to produce them in a safe and standardized way.
Growth factors are natural molecules that act as cellular messengers, they transmit growth, multiplication and regeneration instructions to the different type of cells . They are a fundamental element in the skin good maintenance and healing process . Unfortunately, their concentration levels tend to decrease with age. This is why the collagen destruction process that occurs naturally under the destructive effects of free radicals is not repaired well in older persons.
Growth factors production is a natural process that is naturally boosted by the body when a wound requires tissue reparation. Fractional lasers in aesthetics work based on this exact same process, the doctor create a microscopic wound that triggers EGF production.
Hormones are produced by glands and work on remote sites from where they are produced (this is why it is possible to assume hormones in pills). Growth factors only work locally on the same cells that secrete them.
Yes, it has been shown that EGF significantly helps in the healing of wounds thanks to their strong regenerative process. EGF can be used in areas of the human body damaged in surgery, burns, wounds, or accidents. Research has indicated that EGF increased the rate at which the wound or burn healed. EGF helped to facilitate changes necessary to revert the damaged cells to a younger version of themselves, healing the damaged skin in the process. This is why most of the EGF creams are sold in medical post surgery or post burn creams.
EGF considerably increase skin cell regeneration. More precisely, they will directly communicate to the skin cells to produce more collagen and elastin. Currently, it is the most powerful known active ingredient to induce such stimulation effect. This is why, EGF treatments can reverse ageing signs and restore collagen to levels only observed in young persons.
Several studies demonstrate that EGF not only change the aspect of the skin but they make it healthier and effectively younger. Botox only masks temporarily the signs of time without curing the causes of these signs that is why they are rather considered as complementary treatments.
Results from multiple controlled clinical studies have shown that the application of skin creams containing growth factors:
EGF were first grown in yeast or human cells which was not ideal for medical reasons. Since few years scientists have discovered methods to generate stable growth factors from genetically modified harmless micro-organisms which is ideal from a sanitary point of view.The hyaluronic acid found in many cosmetic creams is produced with the same biotechnological process.
Our recommendation is to limit a treatment with EGF to 4-6 weeks (twice a day) that should be repeated every 3 to 6 month’s depending on the type of skin. In between treatments, we recommend pure creams with these ingredients: hyaluronic acid, peptides, vitamins C, E and B3.
Today, after many independent scientific research, no negative effects have been reported on the use of EGF as cosmetics. Their concentration in the skin after topical application raises to levels similar to natural levels occurring after a small bruise.
However, because they stimulate cell multiplication, the EGF creams are not recommended for people suffering from skin diseases.
Quite the opposite (see here), EGF are non-carcinogens substances found naturally in every human body and a good level of EGF in the skin is usually a sign of a healthy and young skin. Unfortunately, any element that is promoting a good functioning of biological processes such as cell replication (as vitamins for example) in a healthy person, can have unexpected consequences in people suffering from tumours (chemotherapy consists in slowing down all the normal regeneration processes of the body). A reasonable utilisation of EGF products coupled with regular use of sunscreen when sunbathing, helps to promote a very healthy skin.
Because of their medical applications since twenty years and their use in medical (post-burn) creams, their safety of use has been more extensively studied than any other cosmetic ingredient. Other cosmetic creams may contain ingredients for which long-term safety has never been studied. Worse, some creams contains ingredients proven to be harmful (PEG, parabens, sulphates, etc....).
EGF have been extensively studied by the scientific staff of the European Commission who placed them on the “safe cosmetic ingredients list”, which means that they can be safely used in the entire European Union.